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Substance P(SP)、calcitonin gene - related peptide(CGRP) and nitric oxide (NO) may be involved in the transmission of pulpalgia and facial inflammatory pain. 疼痛是牙躰硬組織和牙髓疾患中常見的症狀，也是對活髓牙進行牙躰、牙髓治療操作時令患者恐懼的症狀。